MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C57356.64FB0000" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C57356.64FB0000 Content-Location: file:///C:/267336F5/DL65.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"

Thrombolytics (Streptokinase, Activase)

 


CLASS:

 

ACTION:

 

INDICATION:

 

CONTRAINDICATIONS:

·        Absolute:<= o:p>

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Active int= ernal bleeding

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Suspected = aortic dissection

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Traumatic = CPR (rib fracture, pneumonia)

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Severe persistent hypotension

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Recent head trauma or known intracranial tumor

<= span style=3D'mso-list:Ignore'>o&nb= sp;      History of stroke in last 6 months

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Pregnancy<= o:p>

·        Relative:<= o:p>

<= span style=3D'mso-list:Ignore'>o&nb= sp;      History of trauma/major surgery in past 2 months

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Initial BP= > 180 systolic or 110 diastolic that is controlled by medical treatment<= /o:p>

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Active pep= tic ulcer or blood in stool

<= span style=3D'mso-list:Ignore'>o&nb= sp;      History of stroke, tumor, brain surgery, or head injury

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Known blee= ding disorder or current use of warfarin (coumadin)

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Significant liver dysfunction or kidney failure

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Known canc= er or illness with possible thoracic, abdominal, intracranial abnormalities<= /o:p>

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Prolonged = CPR

 

PRECAUTION:

·        Reperfusion arrhythmias are common once occlusion is opened

 

SIDE EFFECTS:

·        Bleeding/a= llergic reaction/anaphylaxis/fever

 

DOSAGE/ROUTE:

·        Streptokin= ase:        &= nbsp;  1.5 million units over 1 hour IV

·        TPA (Activ= ase):         = 15 mg IV bolus over 1-2 min, IV infusion 50 mg over 1st hr, then 35= mg

over 2nd hr

<= span style=3D'mso-list:Ignore'>o&nb= sp;      Max: 100 m= g

 

 

 

 

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